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| Title | Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 69, Page 1218-1246, Year 2026 |
| Publish date | Aug 1, 2025 (structure data deposition date) |
Authors | Blackwell, J.H. / Lucas, S.C.C. / Battocchio, G. / Borjesson, U. / Bostock, M.J. / Braybrooke, E.L. / Cheung, T. / Cottee, M.A. / Beaumont, K.C. / Gohlke, A. ...Blackwell, J.H. / Lucas, S.C.C. / Battocchio, G. / Borjesson, U. / Bostock, M.J. / Braybrooke, E.L. / Cheung, T. / Cottee, M.A. / Beaumont, K.C. / Gohlke, A. / Hargreaves, D. / van Hoek-Emmelot, M. / van Hoeven, V. / Jansen, C. / Kawatkar, A. / Kinzel, O. / Kumar, P. / Kupcova, L. / Lainchbury, M.D. / Leon, L. / Milbradt, A.G. / Palisse, A. / Schade, M. / van Rijbroek, K. / Sacchetto, C. / Schellekens, R. / Su, N. / Xu, H. / Zhao, H. / Chen, Y. / Huang, S. |
External links | J. Med. Chem. / PubMed:41432228 |
| Methods | X-ray diffraction |
| Resolution | 1.427 Å |
| Structure data | ![]() PDB-9s6m: |
| Chemicals | ![]() PDB-1jl2: ![]() ChemComp-HOH: |
| Source |
|
Keywords | APOPTOSIS / BFL1 / Covalent / Inhibitor |
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homo sapiens (human)
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