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TitleDesign, Synthesis, and Biological Evaluation of the Novel Neutrophil Elastase Inhibitor CHF-6333 for the Inhaled Treatment of Bronchiectasis.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 24869-24889, Year 2025
Publish dateAug 28, 2025 (structure data deposition date)
AuthorsArmani, E. / Rizzi, A. / Miglietta, D. / Bassanetti, I. / Amadei, F. / Brogin, G. / Capaldi, C. / Rancati, F. / Carnini, C. / Xanxo Fernandez, S. ...Armani, E. / Rizzi, A. / Miglietta, D. / Bassanetti, I. / Amadei, F. / Brogin, G. / Capaldi, C. / Rancati, F. / Carnini, C. / Xanxo Fernandez, S. / Civelli, M. / Puccini, P. / Bellini, M. / Jennings, A. / Heald, R.A. / Alcaraz, L. / Sutton, J.M. / Finch, H. / Fitzgerald, M. / Fox, C. / Villetti, G.
External linksJ. Med. Chem. / PubMed:41307403
MethodsX-ray diffraction
Resolution1.14 Å
Structure data

PDB-9si4:
Structure of human neutrophil elastase in complex with a 5,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.14 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-FUC:
alpha-L-fucopyranose

PDB-1jn2:
Crystal Structure of meso-tetrasulphonatophenyl porphyrin complexed with Concanavalin A

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Trypsin Family Fold / Protease / Hydrolase-Inhibitor Complex

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