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TitleMembrane dome-based regulation mechanism of the mechanosensitive PIEZO channel.
Journal, issue, pagesCell Rep, Vol. 44, Issue 12, Page 116651, Year 2025
Publish dateNov 25, 2025
AuthorsYushuang Liu / Bowen Liu / Weiran Zhan / Lun Zhang / Anbing Shi / Long Lin / Man Jiang / Yusong R Guo /
PubMed AbstractPIEZO channels are mechanosensitive ion channels essential for various physiological processes. How activation of PIEZO channels is regulated for distinct mechanical environments remains largely ...PIEZO channels are mechanosensitive ion channels essential for various physiological processes. How activation of PIEZO channels is regulated for distinct mechanical environments remains largely unclear. Here, we use patch-clamp electrophysiology to record pressure-activated currents of natural splicing isoforms of Caenorhabditis elegans PIEZO channels that differ in sequence length. These isoforms are sensitive in different tension regimes, consistent with the quantitative prediction from the membrane dome mechanism, based on structural measurement from cryo-electron microscopy data. Furthermore, these isoforms show different localization in the worm body and are involved in different physiological functions. Therefore, inspired by the membrane dome mechanism, a distinct regulatory strategy is found for PIEZO channels to tune the mechanosensitivity by adjusting the dome area via alternative splicing to adapt to the physiological environment.
External linksCell Rep / PubMed:41296570
MethodsEM (single particle)
Resolution3.4 - 3.8 Å
Structure data

64384

9uox

EMDB-64384, PDB-9uox:
Structure of C. elegans piezo channel isoform k
Method: EM (single particle) / Resolution: 3.8 Å

64385

9uoy

EMDB-64385, PDB-9uoy:
Structure of C. elegans piezo channel
Method: EM (single particle) / Resolution: 3.4 Å

Source
  • caenorhabditis elegans (invertebrata)
KeywordsMEMBRANE PROTEIN / mechanosensitive channel

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