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TitleAdipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.
Journal, issue, pagesScience, Vol. 390, Issue 6773, Page eadr9755, Year 2025
Publish dateNov 6, 2025
AuthorsChao Li / Xue-Nan Sun / Jan-Bernd Funcke / Lauri Vanharanta / Xavier Prasanna / Kaitlynn Gov / Yan Li / Megan Virostek / Chanmin Joung / Nolwenn Joffin / Kristiina Kanerva / Abel Szkalisity / Waldemar Kulig / Leon Straub / Shiuhwei Chen / Joselin Velasco / Ayanna Cobb / Davide La Padula / May-Yun Wang / Toshiharu Onodera / Csaba Vörös / Dae-Seok Kim / Min Kim / Oleg Varlamov / Yang Li / Chen Liu / Andrea R Nawrocki / Shangang Zhao / Da Young Oh / Zhao V Wang / Ruth Gordillo / Joel M Goodman / R Max Wynn / W Mike Henne / Ilpo Vattulainen / Yan Han / Elina Ikonen / Philipp E Scherer /
PubMed AbstractThe microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the ...The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin-Adig complex at an overall resolution of ~3.0 angstroms. The structure revealed that mammalian seipin assembles into two distinct oligomeric forms: undecamers and dodecamers. Adig selectively bound to the dodecameric form and enhanced seipin assembly by bridging and stabilizing adjacent subunits. Functionally, this complex promoted lipid droplet development at both early and late stages. In transgenic mice, adipocyte-specific overexpression of Adig increased fat mass and enlarged lipid droplets, whereas Adig deletion disrupted triglyceride accumulation in brown adipose tissues. Thus, Adig can modulate lipid storage through its structural and functional interactions with seipin.
External linksScience / PubMed:41196993
MethodsEM (single particle)
Resolution2.98 - 3.19 Å
Structure data

45301

9c8d

EMDB-45301, PDB-9c8d:
mouse Seipin/Adig complex
Method: EM (single particle) / Resolution: 2.98 Å

45302

9c8e

EMDB-45302, PDB-9c8e:
mouse Seipin complex
Method: EM (single particle) / Resolution: 3.19 Å

Source
  • mus musculus (house mouse)
KeywordsMEMBRANE PROTEIN / seipin / adipogenin / lipid droplets / adipose

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