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TitleArzanol Inhibits Human Dihydroorotate Dehydrogenase and Shows Antiviral Activity.
Journal, issue, pagesJ. Nat. Prod., Vol. 88, Page 2586-2595, Year 2025
Publish dateJul 18, 2025 (structure data deposition date)
AuthorsAlberti, M. / Tamburello, M. / Salamone, S. / Gallinella, G. / Sanna, C. / Appendino, G.B. / Lolli, M.L. / Massarotti, A. / Pollastro, F. / Miggiano, R.
External linksJ. Nat. Prod. / PubMed:41143446
MethodsX-ray diffraction
Resolution1.61 Å
Structure data

PDB-9s1i:
Crystal structure of human Dihydroorotate Dehydrogenase in complex with arzanol
Method: X-RAY DIFFRACTION / Resolution: 1.61 Å

Chemicals

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-ORO:
OROTIC ACID

PDB-1jkw:
STRUCTURE OF CYCLIN MCS2

ChemComp-ACT:
ACETATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Pyrimidine Biosynthesis / Flavoprotein / DHODH / arzanol

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