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TitleAntibody Mediated Inhibition of HLA/LILR Interactions Breaks Innate Immune Tolerance and Induces Antitumor Immunity.
Journal, issue, pagesCancer Immunol Res, Year 2025
Publish dateAug 6, 2023 (structure data deposition date)
AuthorsPanda, A.K. / Natarajan, K. / Sinha, S. / Jiang, J. / Chempati, S. / Boyd, L.F. / Desai, P.P. / Buszko, M. / Kim, Y.H. / Kazmi, S. ...Panda, A.K. / Natarajan, K. / Sinha, S. / Jiang, J. / Chempati, S. / Boyd, L.F. / Desai, P.P. / Buszko, M. / Kim, Y.H. / Kazmi, S. / Fisk, B. / Teke, M.E. / Larrain, C.M. / Remmert, K. / Blakely, A.M. / Douagi, I. / Hernandez, J.M. / Margulies, D.H. / Shevach, E.M.
External linksCancer Immunol Res / PubMed:41032026
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-8tq5:
Crystal structure of Fab DX17 in complex with MHC-I (HLA-B*44:05)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / histocompatibility complex class I / MHC-I / immune response / immune system Fab / antibody / anti-MHC antibody / cancer tumor

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