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Structure paper

TitleStructural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices.
Journal, issue, pagesNat Commun, Vol. 16, Page 8623-8623, Year 2025
Publish dateApr 3, 2025 (structure data deposition date)
AuthorsDeAngelo, T.M. / Adhikary, U. / Korshavn, K.J. / Seo, H.S. / Brotzen-Smith, C.R. / Camara, C.M. / Dhe-Paganon, S. / Bird, G.H. / Wales, T.E. / Walensky, L.D.
External linksNat Commun / PubMed:41022713
MethodsX-ray diffraction
Resolution1.73 - 1.99 Å
Structure data

PDB-9o14:
Crystal Structure of BCL-2 in complex with a stapled BAD BH3 peptide BAD SAHB 4.2
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-9o15:
Crystal Structure of BCL-2 (G101V) mutant in complex with a stapled BAD BH3 peptide BAD SAHB 4.2
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-9o16:
Crystal Structure of human BCL-2 (R129L) mutant in complex with a stapled BAD BH3 peptide BAD SAHB 4.2
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-NTA:
NITRILOTRIACETIC ACID

ChemComp-HOH:
WATER

ChemComp-IMD:
IMIDAZOLE

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / Apoptosis regulator / stapled peptide

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