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Structure paper

TitleC -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 19269-19286, Year 2025
Publish dateSep 16, 2024 (structure data deposition date)
AuthorsVieira Da Cruz, A. / Perraudin, V. / Minopoli, N. / Iacono, R. / Roig-Zamboni, V. / Bossio, A. / Tangara, S. / Fayolle, M. / Kanazawa, A. / Philouze, C. ...Vieira Da Cruz, A. / Perraudin, V. / Minopoli, N. / Iacono, R. / Roig-Zamboni, V. / Bossio, A. / Tangara, S. / Fayolle, M. / Kanazawa, A. / Philouze, C. / Tarallo, A. / Heming, J.J.A. / Artola, M. / Behr, J.B. / Overkleeft, H.S. / Moracci, M. / Sulzenbacher, G. / Parenti, G. / Py, S.
External linksJ. Med. Chem. / PubMed:40951993
MethodsX-ray diffraction
Resolution1.75 - 2.58 Å
Structure data

PDB-9gsv:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4c
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-9gsw:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4d
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-9gtc:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4g
Method: X-RAY DIFFRACTION / Resolution: 2.58 Å

PDB-9gtd:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4i
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-9gtl:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4j
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-9gtn:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4k
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-9gtt:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4l
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-9gtw:
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 3g
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

PDB-1io6:
GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 (GRB2) C-TERMINAL SH3 DOMAIN COMPLEXED WITH A LIGAND PEPTIDE (NMR, MINIMIZED MEAN STRUCTURE)

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

PDB-1io5:
HYDROGEN AND HYDRATION OF HEN EGG-WHITE LYSOZYME DETERMINED BY NEUTRON DIFFRACTION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

PDB-1io7:
THERMOPHILIC CYTOCHROME P450 (CYP119) FROM SULFOLOBUS SOLFATARICUS: HIGH RESOLUTION STRUCTURAL ORIGIN OF ITS THERMOSTABILITY AND FUNCTIONAL PROPERTIES

PDB-1io8:
Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: High resolution structural origin of its thermostability and functional properties

PDB-1io9:
THERMOPHILIC CYTOCHROME P450 (CYP119) FROM SULFOLOBUS SOLFATARICUS: HIGH RESOLUTION STRUCTURAL ORIGIN OF ITS THERMOSTABILITY AND FUNCTIONAL PROPERTIES

PDB-1ipa:
CRYSTAL STRUCTURE OF RNA 2'-O RIBOSE METHYLTRANSFERASE

PDB-1ipb:
CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

PDB-1ipc:
CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GTP

Source
  • homo sapiens (human)
KeywordsHYDROLASE / acid-alpha-glucosidase / lysosomal / iminosugar / Pompe disease

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