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TitleRational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against alpha-neurotoxins.
Journal, issue, pagesMabs, Vol. 17, Page 2553624-2553624, Year 2025
Publish dateJul 3, 2024 (structure data deposition date)
AuthorsWade, J. / Strancar, N. / Fernandez-Quintero, M.L. / Siebenhaar, S. / Jansen, T. / Meier, E.P.W. / Jenkins, T.P. / Bjorn, S.P. / Nguyen, G.T.T. / Lomonte, B. ...Wade, J. / Strancar, N. / Fernandez-Quintero, M.L. / Siebenhaar, S. / Jansen, T. / Meier, E.P.W. / Jenkins, T.P. / Bjorn, S.P. / Nguyen, G.T.T. / Lomonte, B. / Gutierrez, J.M. / Sorensen, C.V. / Loeffler, J.R. / Paul, A. / Tulika, T. / Arnsdorf, J. / Schoffelen, S. / Lundquist, E.V.S. / Sorensen, J. / Ward, A.B. / Voldborg, B.G. / Bohn, M.F. / Rivera-de-Torre, E. / Morth, J.P. / Laustsen, A.H.
External linksMabs / PubMed:40936197
MethodsX-ray diffraction
Resolution1.32 - 1.6 Å
Structure data

PDB-9fys:
D11 mAbs bound to alpha-Bungarotoxin
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

PDB-9fyt:
mAbs in complex with cobratoxin at pH 4.5
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-9hub:
D11 mAbs bound to alpha-Bungarotoxin at pH 7.5
Method: X-RAY DIFFRACTION / Resolution: 1.33 Å

PDB-9huo:
A01 mAbs bound to cobratoxin at pH 5.5
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-9hxo:
A01 mAbs bound to cobratoxin at pH 6.0
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

Chemicals

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-NA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-K:
Unknown entry

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
  • bungarus multicinctus (many-banded krait)
  • naja kaouthia (monocled cobra)
KeywordsTOXIN / mAbs / bungarotoxin / antibody:toxin complex / cobratoxin / pH / antibody / mAB / pH sensitivity

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