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TitleDesign, Synthesis and Biological Evaluation of 7-(1-Methyl-1 H -indole-3-yl)-5 H -pyrrolo[2,3- b ]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 19415-19437, Year 2025
Publish dateApr 14, 2025 (structure data deposition date)
AuthorsDeng, W. / Chen, X. / Yan, L. / Xiang, S. / Song, X. / Zhang, L. / Li, X. / Zhu, W. / Pei, J. / Lin, X. ...Deng, W. / Chen, X. / Yan, L. / Xiang, S. / Song, X. / Zhang, L. / Li, X. / Zhu, W. / Pei, J. / Lin, X. / Patterson, A.V. / Smaill, J.B. / Li, B. / Tu, Z. / Zhou, Y. / Chen, Y. / Lu, X.
External linksJ. Med. Chem. / PubMed:40921092
MethodsX-ray diffraction
Resolution1.76 - 1.88 Å
Structure data

PDB-9uhc:
FGFR1 kinase domain with a covalent inhibitor 9p
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-9uhi:
FGFR1 kinase domain with a covalent inhibitor 9o
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

Chemicals

PDB-1epe:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

PDB-1epf:
CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Fibroblast growth factor receptor 1 / TRANSFERASE INHIBITOR

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