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TitleMagellon - an extensible platform for cryo-EM data visualization, management and processing.
Journal, issue, pagesIUCrJ, Vol. 12, Issue Pt 6, Page 637-646, Year 2025
Publish dateNov 1, 2025
AuthorsBehdad Khoshbin / Puneeth Damodar / Rupali R Garje / Frank H Schotanus / Nandagopal Nair / Lai Wei / Jan Hannes Schäfer / Gabriel C Lander / Michael A Cianfrocco / Scott M Stagg /
PubMed AbstractSingle-particle cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling high-resolution determination of macromolecular structures. However, the field faces challenges in ...Single-particle cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling high-resolution determination of macromolecular structures. However, the field faces challenges in data management, processing workflow integration and software extensibility. We present Magellon, an innovative cryo-EM software platform that addresses these challenges through a modern microservices architecture. Magellon consists of an extensible backend with a web based frontend that we call Magellon Viewer. Together, these combine high-performance computing capabilities with an intuitive user interface, enabling researchers to efficiently process and analyze cryo-EM data. The platform's distinguishing features include a plugin based architecture, distributed processing capabilities, comprehensive monitoring systems, and a novel approach to data organization and visualization. A key philosophy of the approach is that the Magellon backend provides a platform that uses robust industry-standard libraries to orchestrate computational tasks while offering users and developers flexibility in selecting the computational resources for performing calculations. Magellon represents a significant advancement in cryo-EM software infrastructure, offering flexibility, scalability and extensibility while maintaining ease of use.
External linksIUCrJ / PubMed:40910510 / PubMed Central
MethodsEM (single particle)
Resolution2.7 Å
Structure data

EMDB-49574: Demo apoferritin data for Magellon
Method: EM (single particle) / Resolution: 2.7 Å

Source
  • Mus musculus (house mouse)

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