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-Structure paper
| Title | Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 68, Page 18164-18177, Year 2025 |
| Publish date | Sep 3, 2024 (structure data deposition date) |
 Authors | Ghosh, A. / Ahmed, A. / Amoiradaki, K. / Balazs, A.Y.S. / Barlaam, B. / Bodnarchuk, M.S. / Collie, G.W. / Dale, I.L. / Denz, C.R. / Drew, L. ...Ghosh, A. / Ahmed, A. / Amoiradaki, K. / Balazs, A.Y.S. / Barlaam, B. / Bodnarchuk, M.S. / Collie, G.W. / Dale, I.L. / Denz, C.R. / Drew, L. / Edmondson, S.D. / Fan, J. / Fawell, S. / Goldberg, F.W. / Gopalsamy, A. / Grondine, M. / Guo, G. / Hande, S.M. / Hatoum-Mokdad, H. / Hird, A.W. / Howells, R. / Hao-Ru Hsu, J. / Hudson, J. / Jackson, A. / Lamb, M.L. / Lamont, G.M. / Lamont, S. / Lichtor, P.A. / McWilliams, L. / Milne, D. / Mlynarski, S.N. / Narasimhan, P. / Peters, M.F. / Pflug, A. / Pollard, H.K. / Qin, M. / Reimer, C. / Robbins, K.J. / Robinson, J. / Sha, L. / She, H. / Sheppeck 2nd, J.E. / Singh, B. / Song, K. / Su, Q. / Telmesani, R. / Throner, S. / Vasalou, C. / Wang, L. / Wang, Y. / Wilson, D.M. / Winlow, P. / Yang, W. / Yao, T. / Zhang, Y. / Zhang, Z. / Zindel, D. / Johannes, J.W. |
 External links | J. Med. Chem. / PubMed:40899577 |
| Methods | X-ray diffraction |
| Resolution | 1.16 - 2.45 Å |
| Structure data |  PDB-9gno:  PDB-9gop:  PDB-9gp3: |
| Chemicals |  PDB-1ini:  ChemComp-HOH:  PDB-1ioi:  PDB-1iop: |
| Source |
|
 Keywords | TRANSFERASE / kinase / CDK2 / cancer / inhibitor / AZD8421 |
homo sapiens (human)