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Structure paper

TitleStructural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors.
Journal, issue, pagesNat Commun, Vol. 16, Page 8206-8206, Year 2025
Publish dateMay 29, 2024 (structure data deposition date)
AuthorsKlaushofer, R. / Bloch, K. / Eder, L.S. / Marzaro, S. / Schubert, M. / Bottcher-Friebertshauser, E. / Brandstetter, H. / Dahms, S.O.
External linksNat Commun / PubMed:40897699
MethodsX-ray diffraction
Resolution1.3 - 2.4 Å
Structure data

PDB-9fic:
High-resolution X-ray structure of human PC1/3 (PCSK1) prodomain R77A,R80A,R81A triple-mutant
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-9fid:
X-ray structure of furin (PCSK3) in complex with the PC1/3 (PCSK1) prodomain mutant R78K,R80A
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-9fie:
X-ray structure of furin (PCSK3) in complex with the PC1/3 (PCSK1) prodomain mutant R77A,R80A,R81A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsHYDROLASE / proprotein convertase subtilisin/kexin type 1 / PCSK1 / prodomain / activation / furin / proprotein convertase subtilisin/kexin type 3 / PCSK3 / complex

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