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TitleDiscovery of a widespread chemical signalling pathway in the Bacteroidota.
Journal, issue, pagesNature, Vol. 646, Page 423-432, Year 2025
Publish dateNov 21, 2024 (structure data deposition date)
AuthorsLinares-Otoya, L. / Shirkey, J.D. / Chhetri, B.K. / Mira, A. / Biswas, A. / Neff, S.L. / Linares-Otoya, M.V. / Chen, Y. / Campos-Florian, J.V. / Ganoza-Yupanqui, M.L. ...Linares-Otoya, L. / Shirkey, J.D. / Chhetri, B.K. / Mira, A. / Biswas, A. / Neff, S.L. / Linares-Otoya, M.V. / Chen, Y. / Campos-Florian, J.V. / Ganoza-Yupanqui, M.L. / Jeffrey, P.D. / Hughson, F.M. / Donia, M.S.
External linksNature / PubMed:40836091
MethodsX-ray diffraction
Resolution2.55 - 3.15 Å
Structure data

PDB-9egb:
AclA from Tenacibaculum discolor in complex with substrate
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-9egc:
AclA from Tenacibaculum discolor in complex with the C8-N-acyl cyclolysine reaction product (C8-ACL)
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-9egd:
AclA from Tenacibaculum discolor in complex with intermediate formed by C8-Lysine attack on ADP
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

Chemicals

PDB-1bih:
CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

PDB-1ca3:
UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.

ChemComp-MAE:
MALEIC ACID

ChemComp-HOH:
WATER

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

Source
  • tenacibaculum discolor (bacteria)
KeywordsTRANSFERASE / N-acyl-cyclolysine / biosynthesis / signaling

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