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TitleA Novel, Long-Acting, Small Molecule PKM2 Activator and Its Potential Broad Application Against Photoreceptor Degeneration.
Journal, issue, pagesTransl Vis Sci Technol, Vol. 14, Page 26-26, Year 2025
Publish dateApr 7, 2025 (structure data deposition date)
AuthorsPan, W.W. / Weh, K.M. / Chaudhury, S. / Fernando, R. / Hager, H. / Wen, B. / Chinnaswamy, K. / Stuckey, J.A. / Rech, J.C. / Besirli, C.G. ...Pan, W.W. / Weh, K.M. / Chaudhury, S. / Fernando, R. / Hager, H. / Wen, B. / Chinnaswamy, K. / Stuckey, J.A. / Rech, J.C. / Besirli, C.G. / Weh, E. / Wubben, T.J.
External linksTransl Vis Sci Technol / PubMed:40742037
MethodsX-ray diffraction
Resolution2.416 Å
Structure data

PDB-9o3b:
PKM2 bound to MCTI-566
Method: X-RAY DIFFRACTION / Resolution: 2.416 Å

Chemicals

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-OXL:
OXALATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MG:
Unknown entry

PDB-1b77:
BUILDING A REPLISOME STRUCTURE FROM INTERACTING PIECES: A SLIDING CLAMP COMPLEXED WITH AN INTERACTION PEPTIDE FROM DNA POLYMERASE

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / activator / pyruvate kinase

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