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| Title | Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 16, Page 1209-1216, Year 2025 |
| Publish date | Jan 31, 2025 (structure data deposition date) |
Authors | Liu, B. / Yao, J. / Haimowitz, T. / Benetatos, C.A. / Boyd, S.A. / Condon, S.M. / Burns, C.J. / White, A. / Lakshminarasimhan, D. / Suto, R.K. ...Liu, B. / Yao, J. / Haimowitz, T. / Benetatos, C.A. / Boyd, S.A. / Condon, S.M. / Burns, C.J. / White, A. / Lakshminarasimhan, D. / Suto, R.K. / Cakici, O. / Drager, A.S. / Hart, S.G.E. / Pevear, D.C. / Coburn, G.A. |
External links | Acs Med. Chem. Lett. / PubMed:40666476 |
| Methods | X-ray diffraction |
| Resolution | 2.543 Å |
| Structure data | ![]() PDB-9n3h: |
| Chemicals | ![]() PDB-1bvu: ![]() ChemComp-HOH: |
| Source |
|
Keywords | VIRAL PROTEIN / HBV capsid |
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hepatitis b virus genotype d subtype adw (isolate united kingdom/adyw/1979)
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