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Structure paper

TitleMining the CRBN target space redefines rules for molecular glue-induced neosubstrate recognition.
Journal, issue, pagesScience, Vol. 389, Page eadt6736-eadt6736, Year 2025
Publish dateFeb 21, 2025 (structure data deposition date)
AuthorsPetzold, G. / Gainza, P. / Annunziato, S. / Lamberto, I. / Trenh, P. / McAllister, L.A. / DeMarco, B. / Schwander, L. / Bunker, R.D. / Zlotosch, M. ...Petzold, G. / Gainza, P. / Annunziato, S. / Lamberto, I. / Trenh, P. / McAllister, L.A. / DeMarco, B. / Schwander, L. / Bunker, R.D. / Zlotosch, M. / SriRamaratnam, R. / Gilberto, S. / Langousis, G. / Donckele, E.J. / Quan, C. / Strande, V. / De Donatis, G.M. / Alabi, S.B. / Alers, J. / Matysik, M. / Staehly, C. / Dubois, A. / Osmont, A. / Garskovas, M. / Lyon, D. / Wiedmer, L. / Oleinikovas, V. / Lieberherr, R. / Rubin, N.T. / Lam, D.T. / Lucas, X. / Liardo, E. / Widlund, N.I. / Ritzen, A. / Caceres, R.M. / Vigil, D. / Tsai, J. / Wallace, O. / Peluso, M. / Sadok, A. / Tiedt, R. / Paterson, A.M. / Zarayskiy, V. / Fasching, B. / Bonenfant, D. / Warmuth, M. / Castle, J.C. / Townson, S.A.
External linksScience / PubMed:40608931
MethodsX-ray diffraction
Resolution2.95 - 3.4 Å
Structure data

PDB-9nfq:
Crystal structure of CRBN-DDB1 and MRT-3486 in complex with NEK7
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-9nfr:
Crystal structure of CRBN-DDB1 and MRT-23227 in complex with VAV1
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-9ngt:
Crystal structure of CRBN-DDB1 and FPFT-2216 in complex with mTOR
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

PDB-1bx6:
CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE

ChemComp-ZN:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

PDB-1byx:
CHIMERIC HYBRID DUPLEX R(GCAGUGGC).R(GCCA)D(CTGC) COMPRISING THE TRNA-DNA JUNCTION FORMED DURING INITIATION OF HIV-1 REVERSE TRANSCRIPTION

PDB-1bc8:
STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS

Source
  • homo sapiens (human)
KeywordsDNA Binding Protein/Transferase / Ternary complex / Molecular glue degrader / neosubstrate / DNA Binding Protein-Transferase complex / LIGASE / E3 ligase

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