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Structure paper

TitleA small-molecule VHL molecular glue degrader for cysteine dioxygenase 1.
Journal, issue, pagesNat. Chem. Biol., Vol. 21, Page 1688-1696, Year 2025
Publish dateJan 11, 2024 (structure data deposition date)
AuthorsTutter, A. / Buckley, D. / Golosov, A.A. / Ma, X. / Shu, W. / McKay, D.J.J. / Darsigny, V. / Dovala, D. / Beckwith, R. / Solomon, J. ...Tutter, A. / Buckley, D. / Golosov, A.A. / Ma, X. / Shu, W. / McKay, D.J.J. / Darsigny, V. / Dovala, D. / Beckwith, R. / Solomon, J. / Rao, P. / Xu, L. / Fazal, A. / Lingel, A. / Wartchow, C. / Cobb, J.S. / Hachey, A. / Tullai, J. / Michaud, G.A.
External linksNat. Chem. Biol. / PubMed:40555806
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-8vl9:
Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-8vlb:
Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

PDB-1aci:
L11 RIBOSOMAL PROTEIN RNA BINDING DOMAIN, NMR, 20 STRUCTURES

ChemComp-CIT:
CITRIC ACID

ChemComp-FE2:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-3JF:
N-acetyl-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / VHL / CDO1 / VHL-small molecule-CDO1 ternary complex / degradation

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