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Structure paper

TitleStructural insights into MPXV P1 protein and its orthologs reveal conformational dynamics and a conserved antiviral pocket.
Journal, issue, pagesEmerg Microbes Infect, Vol. 14, Page 2515408-2515408, Year 2025
Publish dateJan 19, 2024 (structure data deposition date)
AuthorsNi, X. / Wang, Y. / Fan, X. / Yu, J. / Lei, J.
External linksEmerg Microbes Infect / PubMed:40476512
MethodsX-ray diffraction
Resolution2.2 - 2.575 Å
Structure data

PDB-8xy1:
Crystal structure of MPXV P1 protein
Method: X-RAY DIFFRACTION / Resolution: 2.575 Å

PDB-8xy2:
Crystal structure of MPXV P1 protein S87P mutant
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-8xy3:
Crystal structure of VARV P1 protein
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8xy4:
Crystal structure of VACV N1 protein
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • monkeypox virus
  • variola virus (smallpox virus)
  • vaccinia virus
KeywordsVIRAL PROTEIN / MPXV / P1 / VARV / VACV / N1

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