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Structure paper

TitleEngineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2501635122-e2501635122, Year 2025
Publish dateDec 5, 2024 (structure data deposition date)
AuthorsOta, N. / Davies, C.W. / Kang, J. / Yan, D. / Scherl, A. / Wong, A. / Cook, R. / Tao, X. / Dunlap, D. / Klabunde, S. ...Ota, N. / Davies, C.W. / Kang, J. / Yan, D. / Scherl, A. / Wong, A. / Cook, R. / Tao, X. / Dunlap, D. / Klabunde, S. / Mantik, P. / Mohanan, V. / Lin, W. / McBride, J. / Sadekar, S. / Storek, K.M. / Lupardus, P. / Ye, Z. / Ackerly Wallweber, H. / Kiefer, J.R. / Xu, M. / Chan, P. / Nagapudi, K. / Yi, T. / Koerber, J.T.
External linksProc. Natl. Acad. Sci. USA / PubMed:40434646
MethodsX-ray diffraction
Resolution1.27 - 2.85 Å
Structure data

PDB-9mdz:
anti-IL23R VHH
Method: X-RAY DIFFRACTION / Resolution: 1.27 Å

PDB-9mfg:
Complex of IL23 receptor and VHH
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SCN:
THIOCYANATE ION

ChemComp-SO4:
SULFATE ION

Source
  • lama glama (llama)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IBD / Inflammatory Bowel Disease / inflammation / immunology

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