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| タイトル | Antigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine. |
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| ジャーナル・号・ページ | Vaccine, Vol. 58, Page 127239, Year 2025 |
| 掲載日 | 2025年6月11日 |
著者 | Shr-Hau Hung / Jonathan L Torres / Fang Chen / Erick Giang / Andrew B Ward / Mansun Law / ![]() |
| PubMed 要旨 | The Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the ...The Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the antigenic properties of the vaccine antigens by immunoassays and EM, revealing inconsistent presentation of AR1/5 epitopes. The vaccine elicited mainly strain-specific neutralizing antibodies in humans and non-human primates, highlighting the need for rational antigen design to improve vaccine breadth. |
リンク | Vaccine / PubMed:40381513 / PubMed Central |
| 手法 | EM (単粒子) |
| 解像度 | 15.17 Å |
| 構造データ | ![]() EMDB-74809: HCV Chiron E1E2 complexed with AR3A and AR4A Fabs |
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万見文献について



著者
リンク
Hepacivirus hominis (ウイルス)