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TitleResistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter -derived cephalosporinase-33 (ADC-33), a class C beta-lactamase present in carbapenem-resistant Acinetobacter baumannii (CR Ab ).
Journal, issue, pagesMbio, Vol. 16, Page e0028725-e0028725, Year 2025
Publish dateNov 25, 2024 (structure data deposition date)
AuthorsPowers, R.A. / Wallar, B.J. / Jarvis, H.R. / Ziegler, Z.X. / June, C.M. / Bethel, C.R. / Hujer, A.M. / Taracila, M.A. / Rudin, S.D. / Hujer, K.M. ...Powers, R.A. / Wallar, B.J. / Jarvis, H.R. / Ziegler, Z.X. / June, C.M. / Bethel, C.R. / Hujer, A.M. / Taracila, M.A. / Rudin, S.D. / Hujer, K.M. / Prati, F. / Caselli, E. / Bonomo, R.A.
External linksMbio / PubMed:40377322
MethodsX-ray diffraction
Resolution1.57 Å
Structure data

PDB-9ehy:
X-ray crystal structure of ADC-33 beta-lactamase in complex with ceftazidime in acyl and product forms
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

Chemicals

PDB-1bim:
CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

ChemComp-CAZ:
ACYLATED CEFTAZIDIME

ChemComp-HOH:
WATER

Source
  • acinetobacter baumannii (bacteria)
KeywordsHYDROLASE / lactamase / complex / cephalosporin / ceftazidime

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