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TitleTandem ketone reduction in pepstatin biosynthesis reveals an F 420 H 2 -dependent statine pathway.
Journal, issue, pagesNat Commun, Vol. 16, Page 4531-4531, Year 2025
Publish dateJul 17, 2024 (structure data deposition date)
AuthorsMo, J. / Sikandar, A. / Zhao, H. / Bashiri, G. / Huo, L. / Empting, M. / Muller, R. / Fu, C.
External linksNat Commun / PubMed:40374670
MethodsX-ray diffraction
Resolution1.65 - 1.8 Å
Structure data

PDB-9g64:
F420-dependent oxidoreductase
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-9gkh:
KvPepIH62A mutant,F420-dependent oxidoreductase
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9gm0:
KvPepI F420-dependent oxidoreductase, F420 complex
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-9gnc:
KvPepIY122A mutant in complex with F420, F420-dependent oxidoreductase
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-9gnd:
KvPepIH62A mutant in complex with F420,F420-dependent oxidoreductase
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-F42:
COENZYME F420

Source
  • streptomyces (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / F420-dependent reductase / Pepstatin biosynthesis / KvPepIH62A mutant / F420-dependent oxidoreductase / KvPepi F420-dependent reductase in complex with F420 / KvPepIY122A mutant in complex with F420 / KvPepIH62A mutant in complex with F420

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