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TitleAdvancing TET Inhibitor Development: From Structural Insights to Biological Evaluation.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 16, Page 804-810, Year 2025
Publish dateJan 8, 2025 (structure data deposition date)
AuthorsWillems, S. / Maksumic, L. / Niggenaber, J. / Lin, T.C. / Schulz, T. / Weisner, J. / Sievers, S. / Muller, M.P. / Summerer, D. / Rauh, D.
External linksAcs Med. Chem. Lett. / PubMed:40365382
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-9hxv:
Crystal structure of TET2-DNA in complex with IOX1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-8XQ:
8-hydroxyquinoline-5-carboxylic acid

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / IOX1 / TET2

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