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Structure paper

TitleTargeting the SHOC2-RAS interaction in RAS-mutant cancers.
Journal, issue, pagesNature, Vol. 642, Page 232-241, Year 2025
Publish dateMay 15, 2024 (structure data deposition date)
AuthorsHauseman, Z.J. / Stauffer, F. / Beyer, K.S. / Molle, S. / Cavicchioli, E. / Marchand, J.R. / Fodor, M. / Viscomi, J. / Dhembi, A. / Katz, S. ...Hauseman, Z.J. / Stauffer, F. / Beyer, K.S. / Molle, S. / Cavicchioli, E. / Marchand, J.R. / Fodor, M. / Viscomi, J. / Dhembi, A. / Katz, S. / Faggion, B. / Lanter, M. / Kerr, G. / Schildknecht, D. / Handl, C. / Maddalo, D. / Pissot Soldermann, C. / Brady, J. / Shrestha, O. / Nguyen, Z. / Leder, L. / Cremosnik, G. / Lopez Romero, S. / Hassiepen, U. / Stams, T. / Linder, M. / Galli, G.G. / Guthy, D.A. / King, D.A. / Maira, S.M. / Thoma, C.R. / Ehmke, V. / Tordella, L.
External linksNature / PubMed:40335703
MethodsX-ray diffraction
Resolution2.04 - 2.73 Å
Structure data

PDB-9btm:
NRas 1-169 Q61R in Complex with Shoc2 80-582
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

PDB-9btn:
Structure of human SHOC2 in complex with a cyclic peptide
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

PDB-9btp:
Structure of human SHOC2 in complex with a small molecule inhibitor (S)-5
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-9ovj:
Structure of human SHOC2 in complex with a small molecule inhibitor (R)-5
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

PDB-1atz:
HUMAN VON WILLEBRAND FACTOR A3 DOMAIN

ChemComp-K:
Unknown entry

PDB-1cf1:
ARRESTIN FROM BOVINE ROD OUTER SEGMENTS

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN/HYDROLASE / SHOC2 / RAS / PP1C / MAPK / Complex / STRUCTURAL PROTEIN / SIGNALING PROTEIN-HYDROLASE complex / Inhibitor

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