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TitleAggrecan immobilizes to perineuronal nets through hyaluronan-dependent and hyaluronan-independent binding activities.
Journal, issue, pagesJ. Biol. Chem., Vol. 301, Page 108525-108525, Year 2025
Publish dateAug 29, 2024 (structure data deposition date)
AuthorsOtsuka, M.Y. / Essel, L.B. / Sinha, A. / Nickerson, G. / Mejia, S.M. / Edge, A. / Matthews, R.T. / Bouyain, S.
External linksJ. Biol. Chem. / PubMed:40273987
MethodsX-ray diffraction
Resolution2.59 - 3.5 Å
Structure data

PDB-9dff:
G1 domain of human aggrecan bound to hyaluronan
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-9dft:
G1 domain of human aggrecan
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsSUGAR BINDING PROTEIN / Extracellular matrix / hyaluronan / chondroitin sulfate proteoglycan

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