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TitleA CK2 alpha ' mutant indicating why CK2 alpha and CK2 alpha ', the isoforms of the catalytic subunit of human protein kinase CK2, deviate in affinity to CK2 beta.
Journal, issue, pagesBiol. Chem., Vol. 406, Page 101-115, Year 2025
Publish dateDec 3, 2024 (structure data deposition date)
AuthorsWerner, C. / Eimermacher, S. / Harasimowicz, H. / Fischer, D. / Pietsch, M. / Niefind, K.
External linksBiol. Chem. / PubMed:40223482
MethodsX-ray diffraction
Resolution1.491 Å
Structure data

PDB-9hk5:
Structure of a mutant of human protein kinase CK2alpha' that equals its isoenzyme CK2alpha in affinity to the regulatory subunit CK2beta
Method: X-RAY DIFFRACTION / Resolution: 1.491 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-3NG:
5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid / chemotherapy, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / human protein kinase CK2 human casein kinase 2 isoenzymes CK2alpha and CK2alpha' CK2alpha/CK2beta interaction

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