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Structure paper

TitleSequence rules for a long SPOP-binding degron required for protein ubiquitylation.
Journal, issue, pagesBiochem. J., Vol. 482, Page 583-600, Year 2025
Publish dateNov 18, 2024 (structure data deposition date)
AuthorsMakhlouf, L. / Mishra, M. / Makhlouf, H. / Manfield, I. / Busino, L. / Zeqiraj, E.
External linksBiochem. J. / PubMed:40178506
MethodsX-ray diffraction
Resolution1.45 - 1.9 Å
Structure data

PDB-9hfu:
Caprin1 peptide bound to SPOP MATH domain
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9hfv:
MyD88 peptide_2 bound to SPOP MATH domain
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-9hfw:
SRC-3 (NCoA-3) peptide bound to SPOP MATH domain
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9hgg:
SETD2 peptide bound to SPOP MATH domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-9hgh:
MyD88 peptide_1 bound to SPOP MATH domain
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / Ubiquitination / Complex / Degradation / Immune signalling

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