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TitleDiscovery of HM-279, a Potent Inhibitor of ALK5 for Improving Therapeutic Efficacy of Cancer Immunotherapy.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 7106-7118, Year 2025
Publish dateAug 22, 2024 (structure data deposition date)
AuthorsArai, M. / Hanada, M. / Taniguchi, H. / Nakajima, F. / Ohmoto, H. / Inoue, T. / Naka, K. / Sawa, M.
External linksJ. Med. Chem. / PubMed:40108955
MethodsX-ray diffraction
Resolution1.337 Å
Structure data

PDB-9j9d:
Crystal structure of ALK5 kinase domain in complex with inhibitor HM-279
Method: X-RAY DIFFRACTION / Resolution: 1.337 Å

Chemicals

PDB-1l30:
REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / Protein kinase / Inhibitor complex

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