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TitleA human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
Journal, issue, pagesSci Transl Med, Vol. 17, Page eadp4754-eadp4754, Year 2025
Publish dateMar 13, 2024 (structure data deposition date)
AuthorsNangle, L.A. / Xu, Z. / Siefker, D. / Burkart, C. / Chong, Y.E. / Zhai, L. / Geng, Y. / Polizzi, C. / Guy, L. / Eide, L. ...Nangle, L.A. / Xu, Z. / Siefker, D. / Burkart, C. / Chong, Y.E. / Zhai, L. / Geng, Y. / Polizzi, C. / Guy, L. / Eide, L. / Tong, Y. / Klopp-Savino, S. / Ferrer, M. / Rauch, K. / Wang, A. / Hamel, K. / Crampton, S. / Paz, S. / Chiang, K.P. / Do, M.H. / Burman, L. / Lee, D. / Zhang, M. / Ogilvie, K. / King, D. / Adams, R.A. / Schimmel, P.
External linksSci Transl Med / PubMed:40073151
MethodsX-ray diffraction
Resolution2.3 - 2.79 Å
Structure data

PDB-8yor:
Complex of HARSWHEP and a-HARSWHEP Fab
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8yp1:
Crystal structure of HARS WHEP domain fused with Fc
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSPLICING/IMMUNE SYSTEM / NRP2 / Lung Inflammation / His-tRNA Synthetase Splice Variant / SPLICING / SPLICING-IMMUNE SYSTEM complex / SPLICING-IMMUNE SYSTEM / His-tRNA Synthetase / Splice Variant

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