+検索条件
-Structure paper
| タイトル | Structure of an F-type phage tail-like bacteriocin from Listeria monocytogenes. |
|---|---|
| ジャーナル・号・ページ | Nat Commun, Vol. 16, Issue 1, Page 1695, Year 2025 |
| 掲載日 | 2025年2月16日 |
著者 | Zhiwei Gu / Xiaofei Ge / Jiawei Wang / ![]() |
| PubMed 要旨 | F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile ...F-type phage tail-like bacteriocins (PTLBs) are high-molecular-weight protein complexes exhibiting bactericidal activity and share evolutionary similarities with the tails of non-contractile siphoviruses. In this study, we present the atomic structure of monocin, a genetically engineered F-type PTLB from Listeria monocytogenes. Our detailed atomic-level analysis, excluding two chaperone proteins, provides crucial insights into the molecular architecture of F-type PTLBs. The core structure of monocin resembles TP901-1-like phage tails, featuring three side fibers with receptor-binding domains that connect to the baseplate for host adhesion. Based on these findings, we propose a potential mechanism by which F-type PTLBs induce cell death, offering a foundation for developing targeted antibacterial therapies. |
リンク | Nat Commun / PubMed:39956822 / PubMed Central |
| 手法 | EM (単粒子) |
| 解像度 | 2.88 - 3.42 Å |
| 構造データ | EMDB-61073, PDB-9j1j: EMDB-61074, PDB-9j1k: EMDB-61075, PDB-9j1l: |
| 化合物 | ![]() ChemComp-FE: |
| 由来 |
|
キーワード | VIRUS LIKE PARTICLE / Bacteriocin / bacteriophage / Siphoviridae / F-type tailocin / phage tail-like bacteriocins / Listeria monocytogenes / monocin / cryo-EM |
ムービー
コントローラー
構造ビューア
万見文献について



著者
リンク






listeria monocytogenes (バクテリア)
キーワード