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TitleDiscovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease.
Journal, issue, pagesAlzheimers Dement (N Y), Vol. 10, Page e70020-e70020, Year 2024
Publish dateApr 3, 2024 (structure data deposition date)
AuthorsKielbasa, W. / Goldsmith, P. / Donnelly, K.B. / Nuthall, H.N. / Shcherbinin, S. / Fleisher, A.S. / Hendle, J. / DuBois, S.L. / Lowe, S.L. / Zhang, F.F. ...Kielbasa, W. / Goldsmith, P. / Donnelly, K.B. / Nuthall, H.N. / Shcherbinin, S. / Fleisher, A.S. / Hendle, J. / DuBois, S.L. / Lowe, S.L. / Zhang, F.F. / Woerly, E.M. / Dreyfus, N.J. / Evans, D. / Gilmore, J. / Mancini, M. / Constantinescu, C.C. / Gunn, R.N. / Russell, D.S. / Collins, E.C. / Brys, M. / Hutton, M.L. / Mergott, D.J.
External linksAlzheimers Dement (N Y) / PubMed:39748851
MethodsX-ray diffraction
Resolution2.54 - 2.75 Å
Structure data

PDB-9ba8:
O-GlcNAcase (OGA) inhibitor complex for the Treatment of Alzheimer's Disease
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

PDB-9ba9:
O-GlcNAcase (OGA) inhibitor complex for the Treatment of Alzheimer's Disease
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

PDB-1akm:
ORNITHINE TRANSCARBAMYLASE FROM ESCHERICHIA COLI

ChemComp-HOH:
WATER

PDB-1akl:
ALKALINE PROTEASE FROM PSEUDOMONAS AERUGINOSA IFO3080

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Inhibitor / Complex / O-GlcNAcase

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