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TitleDiscovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 1134-1154, Year 2025
Publish dateOct 21, 2024 (structure data deposition date)
AuthorsLi, Z. / Harikrishnan, L.S. / Xu, G. / Samanta, D. / Clemente, J.C. / Leng, L. / Tu, W. / Yang, L. / Huang, L. / Wang, M. ...Li, Z. / Harikrishnan, L.S. / Xu, G. / Samanta, D. / Clemente, J.C. / Leng, L. / Tu, W. / Yang, L. / Huang, L. / Wang, M. / Wang, S. / Deng, Q. / Behshad, E. / Nagilla, R. / Orth, P. / Rice, C. / Strickland, C. / Mohammad, H.P. / Priestley, E.S. / Sui, Z.
External linksJ. Med. Chem. / PubMed:39570797
MethodsX-ray diffraction
Resolution1.71 - 2.26 Å
Structure data

PDB-9e1k:
Discovery of Potent, Highly Selective and Efficacious SMARCA2 Degraders - Compound 11
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-9e30:
Discovery of Potent, Highly Selective and Efficacious SMARCA2 Degraders - Compound 13
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

PDB-9e31:
Discovery of Potent, Highly Selective and Efficacious SMARCA2 Degraders - Compound 6
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

PDB-1bf5:
TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

PDB-1a1o:
MHC CLASS I MOLECULE B*5301 COMPLEXED WITH PEPTIDE LS6 (KPIVQYDNF) FROM THE MALARIA PARASITE P. FALCIPARUM

ChemComp-ACT:
ACETATE ION

PDB-1a1p:
COMPSTATIN, NMR, 21 STRUCTURES

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Protein degrader

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