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Structure paper

TitleStructural basis of signaling complex inhibition by IL-6 domain-swapped dimers.
Journal, issue, pagesStructure, Vol. 33, Page 171-180.e5, Year 2025
Publish dateMar 31, 2024 (structure data deposition date)
AuthorsYudenko, A. / Bukhdruker, S. / Shishkin, P. / Rodin, S. / Burtseva, A. / Petrov, A. / Pigareva, N. / Sokolov, A. / Zinovev, E. / Eliseev, I. ...Yudenko, A. / Bukhdruker, S. / Shishkin, P. / Rodin, S. / Burtseva, A. / Petrov, A. / Pigareva, N. / Sokolov, A. / Zinovev, E. / Eliseev, I. / Remeeva, A. / Marin, E. / Mishin, A. / Gordeliy, V. / Gushchin, I. / Ischenko, A. / Borshchevskiy, V.
External linksStructure / PubMed:39566503
MethodsX-ray diffraction
Resolution2.5 - 2.93 Å
Structure data

PDB-8ywp:
Crystal structure of the Fab fragment of anti-IL-6 antibody I9H
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-8ywq:
Crystal structure of the Fab fragment of the anti-IL-6 antibody I9H in complex with a domain-swapped IL-6 dimer
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-8ywr:
Crystal structure of the Fab fragment of the anti-IL-6 antibody 68F2 in complex with a domain-swapped IL-6 dimer
Method: X-RAY DIFFRACTION / Resolution: 2.93 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / interleukin / dimer / swap

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