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Structure paper

TitleMutant-selective AKT inhibition through lysine targeting and neo-zinc chelation.
Journal, issue, pagesNature, Vol. 637, Page 205-214, Year 2025
Publish dateNov 5, 2023 (structure data deposition date)
AuthorsCraven, G.B. / Chu, H. / Sun, J.D. / Carelli, J.D. / Coyne, B. / Chen, H. / Chen, Y. / Ma, X. / Das, S. / Kong, W. ...Craven, G.B. / Chu, H. / Sun, J.D. / Carelli, J.D. / Coyne, B. / Chen, H. / Chen, Y. / Ma, X. / Das, S. / Kong, W. / Zajdlik, A.D. / Yang, K.S. / Reisberg, S.H. / Thompson, P.A. / Lipford, J.R. / Taunton, J.
External linksNature / PubMed:39506119
MethodsX-ray diffraction
Resolution1.9 - 2.2 Å
Structure data

PDB-8uvy:
Structure of AKT1(E17K) with compound 3
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

PDB-8uw2:
Structure of AKT1(E17K) with compound 3 (zinc-free)
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8uw7:
Structure of AKT1(WT) with compound 3
Method: X-RAY DIFFRACTION / Resolution: 1.972 Å

PDB-8uw9:
Structure of AKT1(E17K) with compound 4
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-9c1w:
Structure of AKT2 with compound 3
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL


ChemComp, No image

ChemComp-XOO:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-XQ2:
Unknown entry

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsTRANSFERASE/INHIBITOR / Inhibitor / Kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex

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