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| Title | Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy. |
|---|---|
| Journal, issue, pages | Sci Transl Med, Vol. 16, Page eadm8631-eadm8631, Year 2024 |
| Publish date | Nov 3, 2023 (structure data deposition date) |
 Authors | Caldwell, N. / Peet, C. / Miller, P. / Colon, B.L. / Taylor, M.G. / Cocco, M. / Dawson, A. / Lukac, I. / Teixeira, J.E. / Robinson, L. ...Caldwell, N. / Peet, C. / Miller, P. / Colon, B.L. / Taylor, M.G. / Cocco, M. / Dawson, A. / Lukac, I. / Teixeira, J.E. / Robinson, L. / Frame, L. / Seizova, S. / Damerow, S. / Tamaki, F. / Post, J. / Riley, J. / Mutter, N. / Hanna, J.C. / Ferguson, L. / Hu, X. / Tinti, M. / Forte, B. / Norcross, N.R. / Campbell, P.S. / Svensen, N. / Caldwell, F.C. / Jansen, C. / Postis, V. / Read, K.D. / Huston, C.D. / Gilbert, I.H. / Baragana, B. / Pawlowic, M.C. |
 External links | Sci Transl Med / PubMed:39441903 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.4 Å |
| Structure data |  PDB-8r2a:  PDB-8s00: |
| Chemicals |  ChemComp-LYS: 
ChemComp-XLQ:  ChemComp-GOL:  ChemComp-DMS:  ChemComp-SO4:  ChemComp-HOH:  PDB-1h4w:  ChemComp-TRS: |
| Source |
|
 Keywords | LIGASE / lysine-trna ligase / ATP binding / inhibitor / Cryptosporidium |
cryptosporidium parvum (eukaryote)