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| Title | Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis. |
|---|---|
| Journal, issue, pages | Nat Microbiol, Vol. 9, Page 2817-2835, Year 2024 |
| Publish date | Jan 15, 2024 (structure data deposition date) |
 Authors | Manjunatha, U.H. / Lakshminarayana, S.B. / Jumani, R.S. / Chao, A.T. / Young, J.M. / Gable, J.E. / Knapp, M. / Hanna, I. / Galarneau, J.R. / Cantwell, J. ...Manjunatha, U.H. / Lakshminarayana, S.B. / Jumani, R.S. / Chao, A.T. / Young, J.M. / Gable, J.E. / Knapp, M. / Hanna, I. / Galarneau, J.R. / Cantwell, J. / Kulkarni, U. / Turner, M. / Lu, P. / Darrell, K.H. / Watson, L.C. / Chan, K. / Patra, D. / Mamo, M. / Luu, C. / Cuellar, C. / Shaul, J. / Xiao, L. / Chen, Y.B. / Carney, S.K. / Lakshman, J. / Osborne, C.S. / Zambriski, J.A. / Aziz, N. / Sarko, C. / Diagana, T.T. |
 External links | Nat Microbiol / PubMed:39379634 |
| Methods | X-ray diffraction |
| Resolution | 3 Å |
| Structure data |  PDB-8vof: |
| Chemicals |  PDB-1ade:  ChemComp-SO4:  ChemComp-GDP:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE / Inhibitor complex / chimera / Cryptosporidiosis |
homo sapiens (human)