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TitleCryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 8299, Year 2024
Publish dateSep 27, 2024
AuthorsYaejin Yun / Hyeongseop Jeong / Thibaut Laboute / Kirill A Martemyanov / Hyung Ho Lee /
PubMed AbstractGPR179, an orphan class C GPCR, is expressed at the dendritic tips of ON-bipolar cells in the retina. It plays a pivotal role in the initial synaptic transmission of visual signals from ...GPR179, an orphan class C GPCR, is expressed at the dendritic tips of ON-bipolar cells in the retina. It plays a pivotal role in the initial synaptic transmission of visual signals from photoreceptors, and its deficiency is known to be the cause of complete congenital stationary night blindness. Here, we present the cryo-electron microscopy structure of human GPR179. Notably, the transmembrane domain (TMD) of GPR179 forms a homodimer through the TM1/7 interface with a single inter-protomer disulfide bond, adopting a noncanonical dimerization mode. Furthermore, the TMD dimer exhibits architecture well-suited for the highly curved membrane of the dendritic tip and distinct from the flat membrane arrangement observed in other class C GPCR dimers. Our structure reveals unique structural features of GPR179 TMD, setting it apart from other class C GPCRs. These findings provide a foundation for understanding signal transduction through GPR179 in visual processing and offers insights into the underlying causes of ocular diseases.
External linksNat Commun / PubMed:39333506 / PubMed Central
MethodsEM (single particle)
Resolution3.22 - 4.0 Å
Structure data

35676

8irj

EMDB-35676, PDB-8irj:
Cryo-EM structure of an orphan GPCR
Method: EM (single particle) / Resolution: 3.49 Å

EMDB-35923: Structure of an orphan GPCR, consensus map
Method: EM (single particle) / Resolution: 3.96 Å

EMDB-35924: Structure of an orphan GPCR, component map1
Method: EM (single particle) / Resolution: 3.22 Å

EMDB-35925: Structure of an orphan GPCR, component map2
Method: EM (single particle) / Resolution: 4.0 Å

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / GPCR

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