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-Structure paper
| タイトル | Specialized Listeria monocytogenes produce tailocins to provide a population-level competitive growth advantage. |
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| ジャーナル・号・ページ | Nat Microbiol, Vol. 9, Issue 10, Page 2727-2737, Year 2024 |
| 掲載日 | 2024年9月19日 |
著者 | Nadejda Sigal / Rotem Lichtenstein-Wolfheim / Shai Schlussel / Gil Azulay / Ilya Borovok / Vered Holdengraber / Nadav Elad / Sharon G Wolf / Ran Zalk / Raz Zarivach / Gabriel A Frank / Anat A Herskovits / ![]() |
| PubMed 要旨 | Tailocins are phage tail-like bacteriocins produced by various bacterial species to kill kin competitors. Given that tailocin release is dependent upon cell lysis, regulation of tailocin production ...Tailocins are phage tail-like bacteriocins produced by various bacterial species to kill kin competitors. Given that tailocin release is dependent upon cell lysis, regulation of tailocin production at the single-cell and population level remains unclear. Here we used flow cytometry, competition assays and structural characterization of tailocin production in a human bacterial pathogen, Listeria monocytogenes. We revealed that a specialized subpopulation, constituting less than 1% of the total bacterial population, differentiates to produce, assemble and store thousands of tailocin particles. Tailocins are packed in a highly ordered manner, clustered in a liquid crystalline phase that occupies a substantial volume of the cell. Tailocin production confers a competitive growth advantage for the rest of the population. This study provides molecular insights into tailocin production as a form of altruism, showing how cell specialization within bacterial populations can confer competitive advantages at the population level. |
リンク | Nat Microbiol / PubMed:39300324 |
| 手法 | EM (らせん対称) |
| 解像度 | 2.3 Å |
| 構造データ | EMDB-18416, PDB-8qhs: |
| 化合物 | ![]() ChemComp-HOH: |
| 由来 |
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キーワード | TOXIN / Listeria / monocytogenes / tailocins |
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Listera (植物)
listeria monocytogenes 10403s (バクテリア)
キーワード