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TitlePLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance.
Journal, issue, pagesScience, Vol. 385, Page 1098-1104, Year 2024
Publish dateFeb 19, 2024 (structure data deposition date)
AuthorsParashara, P. / Medina-Pritchard, B. / Abad, M.A. / Sotelo-Parrilla, P. / Thamkachy, R. / Grundei, D. / Zou, J. / Spanos, C. / Kumar, C.N. / Basquin, C. ...Parashara, P. / Medina-Pritchard, B. / Abad, M.A. / Sotelo-Parrilla, P. / Thamkachy, R. / Grundei, D. / Zou, J. / Spanos, C. / Kumar, C.N. / Basquin, C. / Das, V. / Yan, Z. / Al-Murtadha, A.A. / Kelly, D.A. / McHugh, T. / Imhof, A. / Rappsilber, J. / Jeyaprakash, A.A.
External linksScience / PubMed:39236175
MethodsX-ray diffraction
Resolution1.94 - 2.134 Å
Structure data

PDB-8s30:
Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-8s31:
Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18BP1
Method: X-RAY DIFFRACTION / Resolution: 2.134 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / PLK1 / Mis18 complex / Centromere / Chromosome missegregation / Chromosome mis segregation

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