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Structure paper

TitleRational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5.
Journal, issue, pagesEmbo Mol Med, Vol. 16, Page 2539-2559, Year 2024
Publish dateFeb 11, 2024 (structure data deposition date)
AuthorsHarrison, T.E. / Alam, N. / Farrell, B. / Quinkert, D. / Lias, A.M. / King, L.D.W. / Barfod, L.K. / Draper, S.J. / Campeotto, I. / Higgins, M.K.
External linksEmbo Mol Med / PubMed:39223355
MethodsX-ray diffraction
Resolution1.63 - 2.4 Å
Structure data

PDB-8rz0:
Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.016
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

PDB-8rz1:
Synthetic immunogen RH5-34EM bound to monoclonal antibody R5.034
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8rz2:
PfRH5 bound to monoclonal antibody R5.034
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsIMMUNE SYSTEM / Malaria / blood stage / synthetic vaccine immunogen / PfRH5

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