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TitleStructure of anellovirus-like particles reveal a mechanism for immune evasion.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 7219, Year 2024
Publish dateAug 22, 2024
AuthorsShu-Hao Liou / Rajendra Boggavarapu / Noah R Cohen / Yue Zhang / Ishwari Sharma / Lynn Zeheb / Nidhi Mukund Acharekar / Hillary D Rodgers / Saadman Islam / Jared Pitts / Cesar Arze / Harish Swaminathan / Nathan Yozwiak / Tuyen Ong / Roger J Hajjar / Yong Chang / Kurt A Swanson / Simon Delagrave /
PubMed AbstractAnelloviruses are nonpathogenic viruses that comprise a major portion of the human virome. Despite being ubiquitous in the human population, anelloviruses (ANVs) remain poorly understood. Basic ...Anelloviruses are nonpathogenic viruses that comprise a major portion of the human virome. Despite being ubiquitous in the human population, anelloviruses (ANVs) remain poorly understood. Basic features of the virus, such as the identity of its capsid protein and the structure of the viral particle, have been unclear until now. Here, we use cryogenic electron microscopy to describe the first structure of an ANV-like particle. The particle, formed by 60 jelly roll domain-containing ANV capsid proteins, forms an icosahedral particle core from which spike domains extend to form a salient part of the particle surface. The spike domains come together around the 5-fold symmetry axis to form crown-like features. The base of the spike domain, the P1 subdomain, shares some sequence conservation between ANV strains while a hypervariable region, forming the P2 subdomain, is at the spike domain apex. We propose that this structure renders the particle less susceptible to antibody neutralization by hiding vulnerable conserved domains while exposing highly diverse epitopes as immunological decoys, thereby contributing to the immune evasion properties of anelloviruses. These results shed light on the structure of anelloviruses and provide a framework to understand their interactions with the immune system.
External linksNat Commun / PubMed:39174507 / PubMed Central
MethodsEM (single particle)
Resolution2.8 - 3.98 Å
Structure data

27077

8cyg

EMDB-27077, PDB-8cyg:
Cryo-EM structure of TTMV-LY1 anellovirus virus-like particle
Method: EM (single particle) / Resolution: 3.98 Å

43009

8v7x

EMDB-43009, PDB-8v7x:
Cryo-EM structure of TTMV-LY1 anellovirus virus-like particle expressed in HEK293
Method: EM (single particle) / Resolution: 2.8 Å

Source
  • anelloviridae (virus)
  • ttv-like mini virus
KeywordsVIRUS LIKE PARTICLE / anellovirus / Anello Virus: Virus Like Particle (VLP)

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