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Structure paper

TitleStructural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes.
Journal, issue, pagesJ. Biol. Chem., Vol. 300, Page 107702-107702, Year 2024
Publish dateJun 9, 2024 (structure data deposition date)
AuthorsSharma, R. / Amdare, N.P. / Ghosh, A. / Schloss, J. / Sidney, J. / Garforth, S.J. / Lopez, Y. / Celikgil, A. / Sette, A. / Almo, S.C. / DiLorenzo, T.P.
External linksJ. Biol. Chem. / PubMed:39173948
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-9c6v:
Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (1 molecule/asymmetric unit)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9c6w:
Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (2 molecules/asymmetric unit)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-9c6x:
Crystal Structure of a single chain trimer composed of HLA-B*39:01 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-P3G:
3,6,9,12,15-PENTAOXAHEPTADECANE

ChemComp-P4G:
1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HLA CLASS I HISTOCOMPATIBILITY ANTIGEN / B-39 ALPHA CHAIN / BETA-2-MICROGLOBULIN / NLRP2

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