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TitleA photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol.
Journal, issue, pagesChem Sci, Vol. 15, Page 12301-12309, Year 2024
Publish dateMay 6, 2024 (structure data deposition date)
AuthorsReynders, M. / Garscia, M. / Muller-Deku, A. / Wranik, M. / Krauskopf, K. / de la Osa de la Rosa, L. / Schaffer, K. / Jotten, A. / Rode, A. / Stierle, V. ...Reynders, M. / Garscia, M. / Muller-Deku, A. / Wranik, M. / Krauskopf, K. / de la Osa de la Rosa, L. / Schaffer, K. / Jotten, A. / Rode, A. / Stierle, V. / Kraus, Y. / Baumgartner, B. / Ali, A. / Bubeneck, A. / Seal, T. / Steinmetz, M.O. / Paulitschke, P. / Thorn-Seshold, O.
External linksChem Sci / PubMed:39118608
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-9f8g:
Photostatin (photoswitchable azo-combretastatin) Z-PST27 bound to tubulin-DARPin D1 complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

PDB-1ibn:
NMR STRUCTURE OF HEMAGGLUTININ FUSION PEPTIDE IN DPC MICELLES AT PH 5

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
  • synthetic construct (others)
KeywordsCELL CYCLE / tubulin polymerisation inhibitor / microtubule dynamics / antimitotics / photopharmacology / photoswitch / sensitisation

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