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TitleStructural design of the anti-TNF alpha therapeutic NANOBODY® compound, ozoralizumab, to support its potent and sustained clinical efficacy.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 734, Page 150454-150454, Year 2024
Publish dateApr 22, 2024 (structure data deposition date)
AuthorsMima, M. / Mishima-Tsumagari, C. / Nakano, K. / Morimoto, M. / Ogata, H. / Sakata, M. / Iwaoka, R. / Iwata, K. / Hachiuma, K. / Iwamoto, K. ...Mima, M. / Mishima-Tsumagari, C. / Nakano, K. / Morimoto, M. / Ogata, H. / Sakata, M. / Iwaoka, R. / Iwata, K. / Hachiuma, K. / Iwamoto, K. / Fujii, Y. / Kurokawa, T.
External linksBiochem. Biophys. Res. Commun. / PubMed:39083975
MethodsX-ray diffraction
Resolution2.05 - 2.59 Å
Structure data

PDB-8z8m:
Crystal structure of human TNF alpha in complex with TNF30(VHH) domain of ozoralizumab
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-8z8v:
Crystal structure of human serum albumin in complex with ALB8(VHH) domain of ozoralizumab
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / TNF / VHH / Ozoralizumab / TRANSPORT PROTEIN / HSA

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