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TitleIdentification of the Clinical Candidate PF-07284890 ( ARRY-461 ), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 13019-13032, Year 2024
Publish dateApr 17, 2024 (structure data deposition date)
AuthorsRen, L. / Moreno, D. / Baer, B.R. / Barbour, P. / Bettendorf, T. / Bouhana, K. / Brown, K. / Brown, S.A. / Fell, J.B. / Hartley, D.P. ...Ren, L. / Moreno, D. / Baer, B.R. / Barbour, P. / Bettendorf, T. / Bouhana, K. / Brown, K. / Brown, S.A. / Fell, J.B. / Hartley, D.P. / Hicken, E.J. / Laird, E.R. / Lee, P. / McCown, J. / Otten, J.N. / Prigaro, B. / Wallace, R. / Kahn, D.
External linksJ. Med. Chem. / PubMed:39077892
MethodsX-ray diffraction
Resolution1.92 Å
Structure data

PDB-9bfb:
Crystal structure of BRAF kinase domain with PF-07284890
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

PDB-1an9:
D-AMINO ACID OXIDASE COMPLEX WITH O-AMINOBENZOATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Braf inhibitor / kinase domain

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