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Structure paper

TitleTargeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects.
Journal, issue, pagesNucleic Acids Res., Vol. 52, Page 9303-9316, Year 2024
Publish dateAug 30, 2023 (structure data deposition date)
AuthorsHuang, S.C. / Chen, C.W. / Satange, R. / Hsieh, C.C. / Chang, C.C. / Wang, S.C. / Peng, C.L. / Chen, T.L. / Chiang, M.H. / Horng, Y.C. / Hou, M.H.
External linksNucleic Acids Res. / PubMed:39036959
MethodsX-ray diffraction
Resolution1.58 - 2.71 Å
Structure data

PDB-8w76:
Crystal structure of d(CGTATACG)2 duplex
Method: X-RAY DIFFRACTION / Resolution: 2.71 Å

PDB-8w7w:
Crystal structure of d(CGTATACG)2 with acridine complex
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

PDB-8wq7:
Crystal structure of d(CGTATACG)2 with a four-carbon linker containing diacridine compound
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-VZX:
Unknown entry

ChemComp-MG:
Unknown entry


ChemComp, No image

ChemComp-XA5:
Unknown entry

Source
  • synthetic construct (others)
KeywordsDNA / end-to-end junction / helix-helix junction / Drug-DNA complex / bis-intercalator / acridine

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