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TitleIdentification and structural characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3.
Journal, issue, pagesEur. J. Immunol., Vol. 54, Page e2451079-e2451079, Year 2024
Publish dateJan 10, 2024 (structure data deposition date)
AuthorsSim, M.J.W. / Hanada, K.I. / Stotz, Z. / Yu, Z. / Lu, J. / Brennan, P. / Quastel, M. / Gillespie, G.M. / Long, E.O. / Yang, J.C. / Sun, P.D.
External linksEur. J. Immunol. / PubMed:39030753
MethodsX-ray diffraction
Resolution1.7 - 3.5 Å
Structure data

PDB-8rni:
HLA-A*03:01 with KRAS-G12V-10mer
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

PDB-8ro5:
HLA-A3 restricted mG12V-TCR
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8rro:
G12V-TCR complex with HLA-A3
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

PDB-8vjz:
HLA-A*03:01 with WT KRAS-10mer
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HLA-A*03:01 with KRAS-G12V-10mer / HLA-A*03:01 presenting peptide from KRAS (VVVGAGGVGK)

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