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-Structure paper
| タイトル | An intron endonuclease facilitates interference competition between coinfecting viruses. |
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| ジャーナル・号・ページ | Science, Vol. 385, Issue 6704, Page 105-112, Year 2024 |
| 掲載日 | 2024年7月5日 |
著者 | Erica A Birkholz / Chase J Morgan / Thomas G Laughlin / Rebecca K Lau / Amy Prichard / Sahana Rangarajan / Gabrielle N Meza / Jina Lee / Emily Armbruster / Sergey Suslov / Kit Pogliano / Justin R Meyer / Elizabeth Villa / Kevin D Corbett / Joe Pogliano / ![]() |
| PubMed 要旨 | Introns containing homing endonucleases are widespread in nature and have long been assumed to be selfish elements that provide no benefit to the host organism. These genetic elements are common in ...Introns containing homing endonucleases are widespread in nature and have long been assumed to be selfish elements that provide no benefit to the host organism. These genetic elements are common in viruses, but whether they confer a selective advantage is unclear. In this work, we studied intron-encoded homing endonuclease gp210 in bacteriophage ΦPA3 and found that it contributes to viral competition by interfering with the replication of a coinfecting phage, ΦKZ. We show that gp210 targets a specific sequence in ΦKZ, which prevents the assembly of progeny viruses. This work demonstrates how a homing endonuclease can be deployed in interference competition among viruses and provide a relative fitness advantage. Given the ubiquity of homing endonucleases, this selective advantage likely has widespread evolutionary implications in diverse plasmid and viral competition as well as virus-host interactions. |
リンク | Science / PubMed:38963841 / PubMed Central |
| 手法 | EM (サブトモグラム平均) |
| 解像度 | 13.0 Å |
| 構造データ | ![]() EMDB-40674: Subtomogram average of immature PhiKZ Major Capsid Protein from tubular arrays |
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リンク
Phikzvirus phiKZ (ウイルス)