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Title | More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting beta-Coronavirus Replication. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 12261-12313, Year 2024 |
Publish date | May 9, 2023 (structure data deposition date) |
Authors | Ong, H.W. / Yang, X. / Smith, J.L. / Dickmander, R.J. / Brown, J.W. / Havener, T.M. / Taft-Benz, S. / Howell, S. / Sanders, M.K. / Capener, J.L. ...Ong, H.W. / Yang, X. / Smith, J.L. / Dickmander, R.J. / Brown, J.W. / Havener, T.M. / Taft-Benz, S. / Howell, S. / Sanders, M.K. / Capener, J.L. / Counago, R.M. / Chang, E. / Kramer, A. / Moorman, N.J. / Heise, M. / Axtman, A.D. / Drewry, D.H. / Willson, T.M. |
External links | J. Med. Chem. / PubMed:38959455 |
Methods | X-ray diffraction |
Resolution | 2.18 - 2.4 Å |
Structure data | PDB-8p06: PDB-8p07: PDB-9ezg: |
Chemicals | ChemComp-SO4: ChemComp-WAU: ChemComp-HOH: ChemComp-WAP: ChemComp-EDO: PDB-1h8c: |
Source |
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Keywords | TRANSFERASE / Kinase / CK2 / TypI inhibitor / Inhibitor |